Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on beta-cell function in normal living conditions.

L iraglutide is a long-acting glucagonlike peptide (GLP)-1 analog, which exerts its glucose-lowering action through multiple mechanisms (1). One important feature of liraglutide is its ability to enhance -cell function. The effects on -cell function have been demonstrated using standardized -cell function tests based on intravenous glucose administration (2–4). However, these studies may not reflect the modes of action of liraglutide during normal living. To assess the effects of liraglutide on -cell function in normal living, we have used a validated -cell model to analyze 24-h triple-meal experiments.